Rebecca Armbruster, DO, MS, FACOI: Chief Medical Officer | Jeanes Hospital
Rebecca Armbruster, DO, MS, FACOI: Chief Medical Officer | Jeanes Hospital
Calcium transport in mitochondria is essential for cellular energy production and cell survival. Cells use a protein called the mitochondrial sodium-calcium exchanger (NCLX) to maintain calcium balance within these organelles. Recent research led by Dr. John W. Elrod, a professor at the Lewis Katz School of Medicine at Temple University, along with his team, has uncovered a new regulator of NCLX, named TMEM65. This protein assists in moving calcium out of mitochondria, offering protection against calcium overload, which can damage cells.
Dr. Elrod's research, published online on April 8, 2025, in the journal Nature Metabolism, marks the first characterization of the interaction between TMEM65 and NCLX in mitochondria. The findings point towards potential advancements in developing new therapies for conditions like heart failure and Alzheimer’s disease that involve calcium overload in mitochondria.
The study has gained attention from several media outlets, including ScienceDaily, Medical Xpress, and Healthmedicinet.com, who have highlighted the significance of this discovery in the field of medical research.
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